Vaccine Approaches for Pandemic COVID-19
An Overview
DOI:
https://doi.org/10.21467/preprints.108Abstract
The coronavirus strain, SARS-CoV-2 causative agent of the pandemic viral pneumonia disease COVID-19, identified in the late 2019. Unfortunately, there is no vaccine or therapeutics available to control the disease. Although, earlier research efforts of SARS pandemic (2003) provides the precious information to the researchers for fast track vaccine development. Research efforts for vaccine development of COVID-19 pandemic are unprecedented in terms of promising time period. The inactivated whole virus-based SARS-CoV-2 vaccine is first one developed and entered into clinical trial. However, later on after announce of complete genome sequence of SARS-CoV-2, vaccine based on recombinant viral vector, nucleic acid and immunogenic fragment also introduced. Previous experience of undesired immunopotentiation in SARS-CoV studies represents, vaccine safety should be the main concern. Researchers believe that next generation vaccine approaches using recombinant technology such as viral vector or subunit protein-based vaccine will be more effective and safer. This review describes brief information of the major vaccine candidates and the current scenario of vaccine approaches against COVID-19 pandemic.
Keywords:
COVID-19, Vaccine, SARS-CoV-2Downloads
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