Potential role of Curcumin against viral infections with a view on structure and pathogenesis of COVID-19
A novel Coronavirus disease 2019 (nCOVID-19) is an enveloped, positive sense, single stranded RNA viruses of zoonotic origin caused by Severe acute respiratory syndrome coronavirus, currently responsible for pandemic health crisis. Due to increasing mortality rate there is an immediate need to develop possible treatments and understand the mechanism through which virus can cause complications in human body. The review intended to provide link between natural product as treatment and COVID-19 disease. Therefore, this review summarizes the structure, pathogenesis as well as understanding the various role of curcumin as a treatment option for COVID-19 which includes: targeting viral entry to host cells, targeting viral replication, anti-viral, anti-inflammatory and anti-oxidant. Hence, curcumin can be a potential treatment option for COVID-19 patients and this review also suggest that more clinical research and development is needed in order to prepare a new drug for emerging SARS-CoV-2.
Keywords:COVID-19, angiotensin-converting enzyme II (ACE2), Curcumin
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