DOI of the published article https://doi.org/10.1007/s13337-021-00663-w
Cognitive Assessment in Asymptomatic COVID-19 Subjects
DOI:
https://doi.org/10.21467/preprints.231Abstract
Background
Neurological features of COVID-19 have been reported in addition to the respiratory manifestations, but cognitive dysfunction has been scarcely described. And cognitive assessment has not been studied in asymptomatic subjects.
Method
We compared the cognitive assessment scores between asymptomatic SARS-CoV-2 infected subjects with that of controls to detect mild cognitive impairment by the Montreal Cognitive Assessment test.
Result
Asymptomatic COVID-19 subjects secured lower scores in certain domains of the MoCA in comparison with the controls. The domains were visuoperception
(2.4±0.7 vs2.8±0.7, p=0.032), naming (3.6±0.5 vs3.9±0.2, p=0.016) and fluency (0.9±0.6 vs1.6±0.7, p=<0.001). Also, older aged COVID-19 positive subjects scored lower in the MoCA when compared to the younger people.
Conclusion
Our study shows that even otherwise asymptomatic COVID-19 subjects have cognitive deficits in certain subdomains and suggests the need for a detailed psychometric assessment especially in the elderly population.
Keywords:
COVID-19 Neurological, COVID-19 Psychiatric, COVID-19 CognitionDownloads
References
Meier K, Glatz T, Guijt MC, Piccininni M, van der Meulen M, Atmar K, Jolink AT, Kurth T, Rohmann JL, Zamanipoor Najafabadi AH, COVID-19 Survey Study group. Public perspectives on protective measures during the COVID-19 pandemic in the Netherlands, Germany and Italy: A survey study. PloS one. 2020 Aug 5;15 (8): e0236917. https://doi.org/10.1371/journal.pone.0236917
Asadi-Pooya AA, Simani L. Central nervous system manifestations of COVID-19: A systematic review. Journal of the Neurological Sciences. 2020 Apr 11:116832. https://doi.org/10.1016/j.jns.2020.116832
Ahmad I, Rathore FA. Neurological manifestations and complications of COVID-19: A literature review. Journal of Clinical Neuroscience. 2020 May 6. https://doi.org/10.1016/j.jocn.2020.05.017
Zhou H, Lu S, Chen J, Wei N, Wang D, Lyu H, Shi C, Hu S. The landscape of cognitive function in recovered COVID-19 patients. Journal of Psychiatric Research. 2020 Jun 30. https://doi.org/10.1016/j.jpsychires.2020.06.022
Ardila A, Lahiri D. Executive dysfunction in COVID-19 patients. Diabetes & metabolic syndrome. 2020 Jul 22;14(5) :1377-8. https://doi.org/10.1016/j.dsx.2020.07.032
Smith NA, Yeow YY. Use of the Montreal Cognitive Assessment test to investigate the prevalence of mild cognitive impairment in the elderly elective surgical population. Anaesthesia and intensive care. 2016 Sep;44(5) :581-6. https://doi.org/10.1177/0310057X1604400507
Martínez-Banfi M, Vélez JI, Perea MV, García R, Puentes-Rozo PJ, Mebarak Chams M, Ladera V. Neuropsychological performance in patients with asymptomatic HIV-1 infection. AIDS care. 2018 May 4;30 (5) :623-33. https://doi.org/10.3109/00048679209072089
Lal BK, Dux MC, Sikdar S, Goldstein C, Khan AA, Yokemick J, Zhao L. Asymptomatic carotid stenosis is associated with cognitive impairment. Journal of vascular surgery. 2017 Oct 1;66 (4) :1083-92. https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-019-1127-y
Bhat G, Yost G, Mahoney E. Cognitive function and left ventricular assist device implantation. The Journal of Heart and Lung Transplantation. 2015 Nov 1;34 (11) :1398-405. https://doi.org/10.1016/j.healun.2015.05.015
Julayanont P, Nasreddine ZS. Montreal Cognitive Assessment (MoCA): concept and clinical review. InCognitive screening instruments 2017 (pp. 139-195) . Springer, Cham. https://www.concordia.ca/content/dam/artsci/research/caplab/docs/Julayanontetal2013MoCAreview.pdf
Reichard RR, Kashani KB, Boire NA, Constantopoulos E, Guo Y, Lucchinetti CF. Neuropathology of COVID-19: a spectrum of vascular and acute disseminated encephalomyelitis (ADEM) -like pathology. Acta Neuropathologica. 2020 May 24:1-6. https://doi.org/10.1007/s00401-020-02166-2
Polak SB, Van Gool IC, Cohen D, Jan H, van Paassen J. A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression. Modern Pathology. 2020 Jun 22:1-1. https://doi.org/10.1038/s41379-020-0603-3
Kremer S, Lersy F, de Sèze J, Ferré JC, Maamar A, Carsin-Nicol B, Collange O, Bonneville F, Adam G, Martin-Blondel G, Rafiq M. Brain MRI findings in severe COVID-19: a retrospective observational study. Radiology. 2020 Jun 16:202222. https://doi.org/10.1148/radiol.2020202222
Katal S, Balakrishnan S, Gholamrezanezhad A. Neuroimaging findings in COVID-19 and other coronavirus infections: a systematic review in 116 patients. Journal of Neuroradiology. 2020 Jun 27. https://doi.org/10.1016/j.neurad.2020.06.007
Yavarpour-Bali H, Ghasemi-Kasman M. Update on neurological manifestations of COVID-19. Life sciences. 2020 Jul 9:118063. https://doi.org/10.1016/j.lfs.2020.118063
Hu Z, Song C, Xu C, Jin G, Chen Y, Xu X, Ma H, Chen W, Lin Y, Zheng Y, Wang J. Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China. Science China Life Sciences. 2020 May;63 (5) :706-11. https://link.springer.com/article/10.1007/s11427-020-1661-4
Ottestad W, Seim M, Mæhlen JO. COVID-19 with silent hypoxemia. Tidsskrift for Den norske legeforening. 2020 Apr 21. https://tidsskriftet.no/2020/04/kort-kasuistikk/COVID-19-med-stille-hypoksemi
Goodman-Casanova JM, Dura-Perez E, Guzman-Parra J, Cuesta-Vargas A, Mayoral-Cleries F. Telehealth home support during COVID-19 confinement for community-dwelling older adults with mild cognitive impairment or mild dementia: survey study. Journal of Medical Internet Research. 2020;22 (5): e19434. https://www.jmir.org/2020/5/e19434/
Heneka MT, Golenbock D, Latz E, Morgan D, Brown R. Immediate and long-term consequences of COVID-19 infections for the development of neurological disease. Alzheimer's Research & Therapy. 2020 Dec; 12:1-3.https://alzres.biomedcentral.com/articles/10.1186/s13195-020-00640-3
Saunders S, Ritchie K, Russ TC, Muniz-Terrera G, Ritchie CW. Evolution and future directions for the concept of mild cognitive impairment. International Psychogeriatrics. 2018 Oct;30 (10) :1431-4. https://doi.org/10.1017/S1041610217002812
Downloads
Posted
Section
Categories
License
Copyright (c) 2020 Sridhar Amalakanti, Kesava Venkata Raman Arepalli, Jyothi Priya Jillella
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Any non-commercial use, distribution, adaptation, and reproduction in any medium is permitted as long as the original work is properly cited. However, caution and responsibility are required when reusing as the articles on the preprint server are not peer-reviewed. Readers are advised to check for the availability of any updated or peer-reviewed version.
