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The Use of Candida auris Therapies based on Nanotechnology as Potential Novel Strategy against COVID-19 Infection

A Mini Review


  • Gerson Nakazato Universidade Estadual de Londrina
  • Wagner J Favaro Universidade Estadual de Campinas
  • Guillermo R Castro Universidad Nacional de Rosario- CONICET
  • Nelson Duran Universidade Estadual de Campinas



Candida auris, which is one of the causative agents of candidiasis, has been detected in several individuals with immune deficiency worldwide, mainly in different American countries, since 2012. C. auris infections are at risk of becoming epidemic because this species shows multi-drug resistance to several antifungal drugs available in the market; thus, since the current public health condition at global scale is threatened by the SARS-CoV-2 pandemic, C. auris infections could lead to high mortality rates. Different strategies, such as drug repurposing and the combination of antifungal drugs to other biocide molecules, were developed. However, they are time-limited strategies since drug resistance has increased due to C. auris pathologies. As an alternative, the recent development of nanotechnological devices has opened room for the efficient treatment of C. auris infections. Most specifically, the biocide effect of nanoparticles combined to/capped with antifungal drugs in different platforms seems to be an affordable technology to stop invasive C. auris infections.


Candidiasis, Antimicrobials, Nanoparticles, SARS-CoV-2


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