Preprint / Version 1

Possible Prevention of COVID 19 by Using Linoleic Acid (C18) Rich Algae Oil

Authors

  • Venkata Subhash Reliance Technology Group, Reliance Industries Limited
  • Raja Krishna Kumar G Reliance Technology Group, Reliance Industries Limited
  • Ajit Sapre Reliance Technology Group, Reliance Industries Limited
  • Santanu Dasgupta Reliance Industries Limited

DOI:

https://doi.org/10.21467/preprints.36

Abstract

With the rapid spread of COVID 19, people are being isolated in countries, and more than lakhs of people have been infecting by the coronavirus. The coronavirus is an airborne organism and highly infectious at short contact distances. The use of N95 respirators masks (high-efficiency) can protect people against the COVID 19, but the protective efficiency of masks is not high enough. A method of applying oil with rich amounts of linoleic acid in nostrils can prevent the spread of the virus. Macroalgal secondary metabolites have great potential for the development of new drugs and algae derived products largely employed in assorted industries, including agricultural, biomedical, food, and pharmaceutical industries. Among different chemical components isolated from algae, oil components are the most attracting more and which were subjected to a variety of studies (antiviral potential of algae in pharmaceutical research). Algal oil and their components like linoleic acid, oleic acid, palmitic acid, stearic acid are playing a preventive role in the virus infection. In addition, different mechanisms of action have been reported for these linoleic acid (C18H32O2) components, such as inhibiting the binding virus into the host cells or suppressing virulence activity by destabilization of the bilayer of viral envelopes. Application of in controlling the virus entry is mainly depend on the properties like low surface tension, high-boiling point, high viscosity, immiscible with water and antivirus activity. This manuscript mainly discusses the possible physical-chemical mechanisms involved in the application of algal oil and other sources of oils component's role in prevention of viral spread. Among that we listed out various oil sources and their applications in controlling the virus activity. Further confirmed experimental and clinical results for the use of oils as nasal spray may finally contribute to preventing the spread of the coronavirus as soon as possible.

Keywords:

Algal Oil in COVID 19 Control, Linolenic acid (C18) Coronavirus, COVID 19, Nasal spray, Algal Oil

Downloads

Download data is not yet available.

References

American Oil Chemists Society, 2003. AOCS Official Methods and Recommended Practices, fifth ed. AOCS Press, Champaign, pp. 4–38.

Binks, Bernard P., and Tommy S. Horozov, eds. Colloidal particles at liquid interfaces. Cambridge University Press, 2006.

Bligh, E.G. and W.J. Dyer, A rapid method of total lipid extration and purification. Canadian Journal of Biochemistry and Physiology, 1959. 37(8): p. 911-917.

Chisti, Y., Constraints to commercialization of algal fuels. Journal of Biotechnology, 2013. 167(3): p. 201-214.

http://news.dayoo.com/gzrbyc/202002/04/158752_53076829.htm

http://news.ifeng.com/c/7tg6pV2ymEE

http://news.sina.com.cn/c/2020-01-26/doc-iihnzhha4771111.shtml

http://news.sina.com.cn/c/2020-02-02/doc-iimxxste8215056.shtml

https://pib.gov.in/PressReleasePage.aspx?PRID=1600895

https://tech.sina.com.cn/roll/2020-01-30/doc-iimxyqvy9139586.shtml

https://www.2345daohang.com/dianji/64113/item_4521.html

Islam, M., et al., Microalgal Species Selection for Biodiesel Production Based on Fuel Properties Derived from Fatty Acid Profiles. Energies, 2013. 6(11): p. 5676

Loeb, Mark, et al. "SARS among critical care nurses, Toronto." Emerging infectious diseases 10.2 (2004): 251.

Mata, T.M., A.A. Martins, and N.S. Caetano, Microalgae for biodiesel production and other applications: A review. Renewable and Sustainable Energy Reviews, 2010. 14(1): p. 217-232

Milano, J., et al., Microalgae biofuels as an alternative to fossil fuel for power generation. Renewable and Sustainable Energy Reviews, 2016. 58: p. 180-197.

P.Kumari; M.Kumar;C.R.K.Reddy; B.Jha; Algal lipids, fatty acids and sterols. Functional Ingredients from Algae for Foods and Nutraceuticals. 2013. 87-134

Pienkos, P.T. and A. Darzins, The promise and challenges of microalgal-derived biofuels. Biofuels, Bioproducts and Biorefining, 2009. 3(4): p. 431-440

Pôjo, V.N., Challenges of Downstream Processing for the Production of Biodiesel from Microalgae. U.Porto Journal of Engineering, 2017. 3(1): p. 50-60

R. K. Jha and X. Zi-rong, “Biomedical compounds from marine organisms,” Marine Drugs, vol. 2, no. 3, pp. 123–146, 2004.

Ramachandra, T.V., et al., Algal biofuel from urban wastewater in India: Scope and challenges. Renewable and Sustainable Energy Reviews, 2013. 21: p. 767-777

Rothe, Camilla, et al. "Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany." New England Journal of Medicine (2020).

S. Murrell, S.-C. Wu, and M. Butler, “Review of dengue virus and the development of a vaccine,” Biotechnology Advances, vol. 29, no. 2, pp. 239–247, 2011.

S. Zorofchian Moghadamtousi, H. Karimian, R. Khanabdali et al., “Anticancer and antitumor potential of fucoidan and fucoxanthin, two main metabolites isolated from brown algae,” The Scientific World Journal, vol. 2014, Article ID 768323, 10 pages, 2014.

S.-H. Eom, Y.-M. Kim, and S.-K. Kim, “Antimicrobial effect of phlorotannins from marine brown algae,” Food and Chemical Toxicology, vol. 50, no. 9, pp. 3251–3255, 2012.

Schenk, P.M., et al., Second Generation Biofuels: High-Efficiency Microalgae for Biodiesel Production. BioEnergy Research, 2008. 1(1): p. 20-43.

Siddiqui, Nazima, and Adeel Ahmad. "A study on viscosity, surface tension and volume flow rate of some edible and medicinal oils." Int. J. Sci. Environ. Technol 2.6 (2013): 1318-1326.

Subhadra, B. and Grinson-George, Algal biorefinery-based industry: an approach to address fuel and food insecurity for a carbon-smart world. Journal of the Science of Food and Agriculture, 2011. 91(1): p. 2-13.

Thormar, Halldor, et al. "Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides." Antimicrobial agents and chemotherapy 31.1 (1987): 27-31.

Vazquez, Gonzalo, Estrella Alvarez, and Jose M. Navaza. "Surface tension of alcohol water+ water from 20 to 50. degree. C." Journal of chemical and engineering data 40.3 (1995): 611-614.

Yan, Bingpeng, et al. "Characterization of the lipidomic profile of human coronavirus-infected cells: Implications for lipid metabolism remodeling upon coronavirus replication." Viruses 11.1 (2019): 73.

Zhao, Yu, et al. "Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov." BioRxiv (2020).

Zhu, Na, et al. "A Novel Coronavirus from Patients with Pneumonia in China, 2019." New England Journal of Medicine (2020).

Downloads

Posted

2020-04-15

Section

Coronavirus

Categories