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Impact of Coronavirus Pandemic on Immunocompromised Patients

A Detailed Review


  • Rupalakshmi Vijayan Larkin Community Hospital, South Miami, Florida
  • Ayesha Zulfiqar Larkin Community Hospital, South Miami, Florida
  • Fernanda Rodrigues Carlos Nunes Larkin Community Hospital, South Miami, Florida
  • Pedro Gabriel Paiva Bueno Larkin Community Hospital, South Miami, Florida
  • Shavy Nagpal The Research Institute of St. Joe's Hamilton
  • Raghava Ambadapoodi Larkin Community Hospital, South Miami, Florida
  • China Rahman The Research Institute of St. Joe's Hamilton
  • Samia Islam The Research Institute of St. Joe's Hamilton
  • Steve Lippmann Larkin Community Hospital, Florida



Background:  The coronavirus (COVID-19) pandemic has been stressful for everyone across the globe and even more so for the immunocompromised population, bringing with it an enormous emotional impact on their lives. Fear and anxiety regarding this novel disease created a state of panic among the public. The aim was to review published cases of COVID-19 and to discuss pandemic related anxiety and stress in immunocompromised populations and describe their presentations, diagnostic processes, clinical characteristics and outcomes.

Methods: Using specific keywords, a review of scientific literature was conducted in databases such as PubMed, Google Scholar including systematic reviews, meta-analysis, case series, and case reports. Of 35 articles, 22 studies were reviewed.

Results: Of the 22 studies involved, a few of the studies had significant data. Among 603 ovarian cancer patients, 88.6% were worried, 51.4% anxious, and 26.5% depressed due to COVID-19 related delay in care. Among 167 people living with HIV patients, 25% reported generalized anxiety disorder. In another cross-sectional study with 500 respondents, anxiety (aOR = 1.73; 95% CI, 1.25–2.40, p-value = 0.001), depression and anxiety (aOR = 1.80; 95% CI, 1.28–2.53, p-value <0.001), and mental health deterioration (aOR = 1.94; 95% CI, 1.48–2.55, p-value <0.001) on basis of fear of the COVID pandemic was noted.

Conclusion: As a conclusion, these articles demonstrated that patients with immunocompromised states had more symptoms of anxiety and fear as compared to the immunocompetent patients. Most of the patients had concerns of fear about future health implications, concern over social implications, and possible financial difficulties encountered and remained infectious for a longer duration with severe anxiety symptoms.


COVID-19, Immunocompromised, HIV


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