Outfitting COVID-19: An Effective Therapeutic Approach
Use of antisense oligonucleotides of the type 3'-(N)x-AAAUUUG-(N)x-5' against slippery sequence and polynucleotides against pseudoknots forming sequences of SARS-CoV-2 RNA would block the first translation of ORF1a and ORF1b and hence dwindle the virus replication. It is easy to synthesize and deliver the antisense oligonucleotides to the target by directly injecting the nano formulation into the blood.
Keywords:Oligonucleotides, Nanoparticle, Slippery sequence, Pseudoknots
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