Preprint / Version 1

Impact of COVID-19 on Physiology Research: Global Lessons Learned and Future Recommendations


  • Jeet Patel Department of Biological Sciences, Halmos College of Arts and Sciences, Nova Southeastern University
  • Santanu De Department of Biological Sciences, Halmos College of Arts and Sciences, Nova Southeastern University



The Coronavirus Infectious Disease 2019 (COVID-19) pandemic caused massive changes in not only the medical field but every aspect of the world. As the whole world moved from in-person to remote, students found themselves in a predicament where they were forced to take school online, from home. This would mean that all projects, research, tests, and meetings were conducted over Zoom or other online meeting platforms. Labs were shut down or only a limited number of people were allowed to enter to conduct the necessary research. In this paper, the field of physiological research throughout the world will be discussed, and how the COVID-19 pandemic has affected the research process of all anatomical fields and experiments themselves. An extensive literature review of many published reports has been conducted for the study. The purpose of this is to better understand the impact of COVID-19 on the vast area of physiological studies and research.  Experiments that were being conducted were halted, which could change the entirety of the results. A major issue found is that volunteers were at a minimum, specifically in the ages greater than 65 years, were scarce as they refused to volunteer due to COVID-19 risk or various other reasons. As the volunteers began to drop, experiments conducted by students were forced to change to an online-only format. Medical students were forced to conduct physiological research from home as they spoke with volunteers over the phone. This not only changes the results coming in but also the learning progression for the students. This comprehensive literature review analysis summarizes how, among multifarious short- and/or long-term consequences of the pandemic in practically every sphere, the area of physiological research was drastically impacted.


COVID-19, global impact and recommendations, physiology research


Download data is not yet available.


C. S. Deane et al., “Exploring the Impact of COVID-19 on the Willingness of Older Adults to Participate in Physiology Research: Views from past and Potential Volunteers,” Applied Physiology, Nutrition, and Metabolism, pp. 1–5, Jun. 2021, doi:

N. Gobat et al., “What the Public Think about Participation in Medical Research during an Influenza pandemic: an International cross-sectional Survey,” Public Health, vol. 177, pp. 80–94, doi:

K. J. Manton, C. S. Gauld, K. M. White, P. M. Griffin, and S. L. Elliott, “Qualitative Study Investigating the Underlying Motivations of Healthy Participants in Phase I Clinical Trials,” BMJ Open, vol. 9, no. 1, p. e024224, doi:

“THE AMERICAN PHYSIOLOGICAL SOCIETY (APS) IS a COMMUNITY THAT CHAMPIONS THE DISCIPLINE OF PHYSIOLOGY | Research on Pause: the Effects of the Coronavirus on Physiology,” 2022. Available:

UK Health Security Agency, “COVID-19 Vaccination Programme,” GOV.UK, 2022. (accessed Dec. 2022).

P. R. Padala et al., “Participant and Caregiver Perspectives on Clinical Research During Covid?19 Pandemic,” Journal of the American Geriatrics Society, 2021, doi:

S. Ahmed et al., “Vaccine Development against COVID-19: Study from Pre-Clinical Phases to Clinical Trials and Global Use,” Vaccines, vol. 9, no. 8, p. 836, 2021, doi:

M. J. Tobin, A. Jubran, and F. Laghi, “Noninvasive Strategies in COVID-19: epistemology, Randomised trials, guidelines, Physiology,” European Respiratory Journal, vol. 57, no. 2, p. 2004247, doi:

Centers for Disease Control and Prevention, “CDC Updates and Shortens Recommended Isolation and Quarantine Period for General Population,”, Dec. 27, 2021.

M. C. Stenson, J. K. Fleming, S. L. Johnson, J. L. Caputo, K. E. Spillios, and A. E. Mel, “Impact of COVID-19 on Access to Laboratories and Human participants: Exercise Science Faculty Perspectives,” Advances in Physiology Education, vol. 46, no. 2, pp. 211–218, Jun. 2022, doi:

S. M. Barman, L. Csernoch, and J. Sengupta, “Physiological Societies across the Globe Unite in an Effort to Handle the COVID-19 Pandemic,” Physiology, vol. 36, no. 2, pp. 62–70, 2021, doi:

J. N. Cronin, L. Camporota, and F. Formenti, “Mechanical Ventilation in COVID?19: a Physiological Perspective,” Experimental Physiology, 2021, doi:

S. C. Auld et al., “ICU and Ventilator Mortality among Critically Ill Adults with Coronavirus Disease 2019,” Critical Care Medicine, vol. 48, no. 9, 2021, doi:

J. Xi, B. Walfield, X. A. Si, and A. A. Bankier, “Lung Physiological Variations in COVID-19 Patients and Inhalation Therapy Development for Remodeled Lungs,” SciMedicine Journal, vol. 3, no. 3, pp. 198–208, 2021, doi:

L. Ball et al., “Computed tomography assessment of PEEP-induced alveolar recruitment in patients with severe COVID-19 pneumonia,” Critical Care, vol. 25, no. 1, 2021, doi:

Z. Wu et al., “Structural and Physiological Changes of the Human Body upon SARS-CoV-2 Infection,” Journal of Zhejiang University. Science. B, vol. 22, no. 4, pp. 310–317, 2021, doi:

I. Cliff, N. Mustfa, I. Hussain, E. Munro, H. Bishop, and H. Stone, “Impact of the COVID-19 Pandemic on a Respiratory Physiology Department and the Patient’s Perception of Rapid Service Change,” BMJ Leader, p. leader-2021-000463, Jan. 2022, doi:

N. Ziauddeen et al., “Characteristics and impact of Long Covid: Findings from an online survey,” PLOS ONE, vol. 17, no. 3, p. e0264331, Mar. 2022, doi:

A. Dennis et al., “Multiorgan Impairment in low-risk Individuals with post-COVID-19 syndrome: a prospective, community-based Study,” BMJ Open, vol. 11, no. 3, p. e048391, 2021, doi:

R. Astin et al., “Long COVID: mechanisms, risk factors and recovery,” Experimental Physiology, Nov. 2022, doi:

R. Higgins, F. Murphy, and P. Hogg, “The Impact of Teaching Experimental Research on-line: Research-informed Teaching and COVID-19,” The Impact of Teaching Experimental Research on-line: Research-informed Teaching and covid-19, doi:

R. Riedl, “On the Stress Potential of videoconferencing: Definition and Root Causes of Zoom Fatigue,” Dec. 2021, doi:

T. B. Becker et al., “The Impact of COVID-19 on Student Learning during the Transition from Remote to in-person learning: Using Mind Mapping to Identify and Address Faculty Concerns,” Advances in Physiology Education, vol. 46, no. 4, pp. 742–751, Dec. 2022, doi:

M. Kilcullen, J. Feitosa, and E. Salas, “Insights from the Virtual Team Science: Rapid Deployment during COVID-19,” Human Factors: the Journal of the Human Factors and Ergonomics Society, 2021, doi:

R. Abdul Razzaq, T. Al-Shaibani, and Y. Naguib, “Do Students Effectively Learn Physiology through Distance Online Instruction? Medical Students’ Perceptions and Academic Performance,” Advances in Physiology Education, 2021, doi:

“THE AMERICAN PHYSIOLOGICAL SOCIETY (APS) IS a COMMUNITY THAT CHAMPIONS THE DISCIPLINE OF PHYSIOLOGY | Research on Pause: the Effects of the Coronavirus on Physiology,” 2022. Available:

“The American Physiology Society (APS): The Effects of the Coronavirus on Physiology.” Available:

J. A. Singh, S. V. Bandewar, and E. A. Bukusi, “The Impact of the COVID-19 Pandemic Response on Other Health Research,” Bulletin of the World Health Organization, vol. 98, no. 9, pp. 625–631, 2021, doi:

M. Prudêncio and J. C. Costa, “Research Funding after COVID-19,” Nature Microbiology, vol. 5, no. 8, pp. 986–986.

G. Leftheriotis, D. Noble, S. Wray, and E. Vidal-Petiot, THE TRIBUTE OF PHYSIOLOGY FOR THE UNDERSTANDING OF COVID-19 DISEASE. Frontiers, 2021.

J. Walker, C. Brewster, and R. Fontinha, “The unintended consequences of the pandemic on non-pandemic research activities,”, 2022.