Preprint / Version 1

The Action of Platelet-Rich Plasma (PRP) in Cardiovascular Disease Treatment

Authors

  • Nelson Duran Institute of Biology, University of Campinas
  • Wagner J Fávaro State University of Campinas
  • Angela C M Luzo Laboratory of Urogenital Carcinogenesis and Immunotherapy, Department of Structural and Functional Biology, University of Campinas (UNICAMP)

DOI:

https://doi.org/10.21467/preprints.514

Abstract

Atherosclerosis, or coronary artery disease, is an inflammatory disorder capable of affecting large arteries. It is also the main cause of cardiovascular disease and stroke, and its main causative factors lie on lipid accumulation in, and inflammation of, large arteries. The aim of the current study is to investigate the need of conducting better therapeutic assessments in more clinically relevant animal models of ischemic stroke, as well as the action of platelet rich plasma in modulating inflammatory processes in cardiac injury cases.

Keywords:

PRP, Cardiovascular, Therapy

Downloads

Download data is not yet available.

References

SBC-2022: https://www.opovo.com.br/ noticias/saude/2022/09/28/brasil-pode-ter-400-mil-mortes-por-doencas-do-coracao-em-2022.html

SBC-2019: https://www.portal.cardiol.br/

Bjorkegren JLM, Lusis AJ. Atherosclerosis: Recent developments. Cell 2022; 185: 1630-45.

Ayoub M. Pathogenesis of atherosclerosis: Review. J Pharm Res Inter 2022; 34: 54-62.

Perrotta, I. Atherosclerosis: From molecular biology to therapeutic perspective. Int J Mol Sci 2022; 23: 3444.

Liu C, Jiang Z, Pan Z, Yang L The function, regulation and mechanism of programmed cell death of macrophages in atherosclerosis. Front Cell Dev Biol. 2922; 9: 809516.

Forteza MJ, Ketelhuth DFJ. Metabolism in atherosclerotic plaques: immunoregulatory mechanisms in the arterial wall. Clin Sci 2022; 136: 435–54.

Zhang X, Takeuchi M, Ohkawa M, Matsuzawa N. Provenance of a Permian accretionary complex (Nishiki Group) of the Akiyoshi Belt in Southwest Japan and Paleogeographic implications. J Asian Earth Scie 2018; 5: 130.

Libby P, Buring JE, Badimon L, Hansson GK, Deanfield J, Bittencourt MS, et al. Atherosclerosis. Nat Rev Dis Primers. 2019; 5: 56.

Libby P. The changing landscape of atherosclerosis. Nature. 2012; 592: 524-533.

Gimbrone MAJr, Garc?a-Cardena G. Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circ Res 2016; 118: 620–36.

Luo X, Lv Y, Bai X, Qi J, Weng X, Liu S, et al. Plaque erosion: a distinctive pathological mechanism of acute coronary syndrome. Front Cardiovasc Med 2021; 8: 711453.

Favero G, Paganelli C, Buffoli B, Rodella LF, Rezzani R. Endothelium and its alterations in cardiovascular diseases: Life style intervention. BioMed Res Int 2014; 2014: 801896.

Campinho P, Vilfan A, Vermot J. Blood flow forces in shaping the vascular system: A focus on endothelial cell behavior. Front Physiol 2020; 11: 552.

Davies PF. Flow-mediated endothelial mechanotransduction. Physiol Rev 1995; 75: 519–60.

Esper RJ, Nordaby RA, Vilariño JO, Paragano A, Cacharrón JL, Machado RA. Endothelial dysfunction: A comprehensive appraisal. Cardiovasc Diabetol 2006; 18: 1–18.

Gimbrone MAJr, García-Cardeña G. Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis. Cardiovasc Pathol 2013; 22: 9–15.

PDAY, 1993. Natural history of aortic and coronary atherosclerotic lesions in youth. findings from the PDAY study. Pathobiological determinants of atherosclerosis in youth (PDAY) Research Group. Arter Thromb A J Vasc Biol 1993; 13: 1291–98.

Jebari-Benslaiman S, Galicia-García U, Larrea-Sebal A, Olaetxea J, Alloza I, Vandenbroeck K, et al. Pathophysiology of atherosclerosis. Int J Mol Sci 2022; 23: 3346.

Suryawan IGR, Andrianto, Anggaraeni AD, Agita A, Nugraha RA. The role of human platelet-rich plasma to enhance the differentiation from adipose derived mesenchymal stem cells into cardiomyocyte: An experimental study. bioRxiv Preprint doi: https://doi.org/10.1101/ 2020.12.10.420679.

Lobo Filho HG, Ferreira NJ, de Sousa RB, de Carvalho ER, Lobo PLD, Lobo Filho JG. Experimental model of myocardial infarction induced by isoproterenol in rats. Rev Bras Cir Cardiovasc 2011;26: 469-76.

Kaluza GL, Creech JL, Furer A, Afari ME, Milewski K, Yi G-H, et al. Chronic myocardial and coronary arterial efects of intracoronary supersaturated oxygen therapy in swine with normal and ischemic reperfused myocardium. Sci Rep 2022; 12: 5785.

Lee YT, Laxton V, Lin HY, Chan YWF, Fitzgerald Smith S, To TLO, et al. Animal models of atherosclerosis (Review). Biomed Rep 2017; 6: 259-66.

Poznyak AV, Silaeva YY, Orekho AN, Deykin AV. Animal models of human atherosclerosis: Current progress. Brazil J Med Biol Res 2020; 53: e9557.

Spartalis E, Tomos P, Mori D, Athanasiou A, Markakis C, Spartalis MD, et al. Role of platelet-rich plasma in ischemic heart disease: An update on the latest evidence. World J Cardiol 2015; 26; 7: 665-70

Solanes N, Bobi J, Arrieta M, Jimenez FR, Palacios C, Rodríguez JJ, et al. An open secret in porcine acute myocardial infarction models: The relevance of anaesthetic regime and breed in ischaemic outcomes. Front Vet Sci 2022; 9: 919454.

Kaiser EE, West FD. Large animal ischemic stroke models: replicating human stroke pathophysiology. Neural Regen Res 2020; 15:1377-87.

Melo BAG, Luzo ACM, Lana JF, Santana MHA. Centrifugation conditions in the L-PRP preparation affect soluble factors release and mesenchymal stem cells proliferation in fibrin nanofibers. Molecules 2019; 24: 2729.

Imam SS, Al-Abbasi FA, Hosawi S, Afzal M, Nadeem MS, Ghoneim MM, et al. Role of platelet rich plasma mediated repair and regeneration of cell in early stage of cardiac injury. Regen Ther 2022; 19: 144-53.

Luzo ACM, Leme, KC, Fávaro WJF, Durán N, Bíscaro, GG, de Oliveira ALR , Boumediene K, Hammad M, Baugé C. Platelet-rich plasma, their growth factors, cytokines and clinical use. In Nanotechnology and Regenerative Medicine History, Techniques, Frontiers, and Applications (Ed. M.H.A. Santana, E. Souto, R. Shegoka) Academic Press, Chapter 11 , pp 265-314, 2023. SBN-13: 978-0323904711, ISBN-10: 0323904718

Durán G, Luzo ACM, Fávaro WJ, Durán N. Nanostructured platelet-rich plasma: state of art in dental treatments. Braz J Dental Sci 2020; 23: 1838.

Durán N, Fávaro WJ, Durán G, Bíscaro GG, Lemes KC, Luzo ACM. Using platelet-rich plasma against trigeminal neuralgia: Is it an alternative? a mini-review. AIJR Preprint. In press, 2022.

Gallo I, Sáenz A, Arévalo A, Roussel S, Pérez-Moreiras I, et al. Effect of autologous platelet-rich plasma on heart infarction in sheep. Arch Cardiol Mex 2013; 83: 154-58.

Hargrave B, Li F. Nanosecond pulse electric field activation of platelet-rich plasma reduces myocardial infarct size and improves left ventricular mechanical function in the rabbit heart. J Extra Corpor Technol 2012;44: 198-204.

Mishra A, Velotta J, Brinton TJ, Wang X, Chang S, Palmer O, et al. RevaTen platelet-rich plasma improves cardiac function after myocardial injury. Cardiovasc Revasc Med 2011; 12: 158-163.

Vu TD, Pal SN, Ti LK, Martinez EC, Rufaihah AJ, Ling LH, et al. An autologous platelet-rich plasma hydrogel compound restores left ventricular structure, function and ameliorates adverse remodeling in a minimally invasive large animal myocardial restoration model: a translational approach: Vu and Pal “Myocardial Repair: PRP, Hydrogel and Supplements”. Biomaterials 2015; 45: 27-35.

Yu FX, Zhang Y, Tran N, Fu Y, Liao B, Shi YK. Effects of myocardial platelet rich plasma injection on rats with acute myocardial infarction:(99)Tc(m)- MIBI gated SPECT imaging evaluation results]. Zhonghua Xinxueguanbing Zazhi 2012; 40: 392-96.

Li XH, Zhou X, Zeng S, Ye F, Yun JL, Huang TG, et al. Effects of intramyocardial injection of platelet-rich plasma on the healing process after myocardial infarction. Coron Artery Dis 2008; 19: 363-370.

Sun CK, Zhen YY, Leu S, Tsai TH, Chang LT, Sheu JJ, Chen Y-L, et al. Direct implantation versus platelet-rich fibrin-embedded adipose-derived mesenchymal stem cells in treating rat acute myocardial infarction. Int J Cardiol 2014; 17: 410- 23.

Wehberg KE, Answini G, Wood D, Todd J, Julian J, Ogburn N, et al.Intramyocardial injection of autologous platelet-rich plasma combined with transmyocardial revascularization. Cell Transplant. 2009; 18: 353-59.

Rah DK, Min HJ, Kim YW, Cheon YW. Effect of platelet-rich plasma on ischemia-reperfusion injury in a skin flap mouse model. Int J Med Sci 2017; 14: 829-39.

Ferrara N. Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol 2001; 280: C1358-C136.

Brill A, Dashevsky O, Rivo J, Gozal Y, Varon D. Platelet-derived microparticles induce angiogenesis and stimulate post-ischemic revascularization. Cardiovasc Res 2005; 67:30-8.

Carmeliet P. Angiogenesis in health and disease. Nat Med 2003; 9: 653-60.

Hehanusa RR, Andrianto, Pikir BS. Effect of platelet rich plasma (PRP) on proliferation of endothelial progenitor cell (EPC) of stable coronary artery disease patient. Indonesian J Cardiol 2019; 40: 258-61.

Bir S, Esaki J, Marui A, Yaahara K, Tsubota H, Ikeda T, et al. Angiogenic properties of sustained release platelet-rich plasma: Characterization invitro and in the ischemic hind limb of the mouse. Vasc Surgery. 2009; 50:870-878.

da Silva LQ, Justo-Junior AS, Martinelli BM, da Cruz MA, Huber SC, Montalvão SAL, et al. The role of platelet-rich plasma in the mild and severe stages of atherosclerotic disease in mice, Regen Med 2022; 17: 259-70.

Chen L, Zhou Z, Hu C, Maitz MF, Yang L, Luo R, et al. Platelet membrane-coated nanocarriers targeting plaques to deliver anti-cd47 antibody for atherosclerotic therapy. AAAS Res. 2022; 2022: ID 9845459.

Karin M, Clevers H. Reparative inflammation takes charge of tissue regeneration. Nature. 2016; 529: 307-15.

Huber SC, Cunha Júnior JLR, Montalvao S, da Silva LQ, Paffaro AU, da Silva FAR, et al. In vitro study of the role of thrombin in platelet rich plasma (PRP) preparation: utility for gel formation and impact in growth factors release. J Stem Cells Regen Med 2016;12: 2-9

Xie X, Wang Y, Zhao C, Guo S, Liu S, Jia W, et al. Comparative evaluation of MSCs from bone marrow and adipose tissue seeded in PRP-derived scaffold for cartilage regeneration. Biomaterials 2012; 33: 7008-18.

Giannopoulou M, Dai C, Tan X, Wen X, Michalopoulos GK, Liu Y. Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kb signaling. Am J Pathol 2008; 173:30-41.

Saxena A, Khosraviani S, Noel S, Mohan D, Donner T, Hamad ARA. Interleukin-10 paradox: A potent immunoregulatory cytokine that has been difficult to harness for immunotherapy. Cytokine 2015; 74: 27-34.

Zhang J-M, An J. Cytokines, inflammation, and pain. Int Anesthesiol Clin 2007; 45: 27-37.

Kendall RT, Feghali-Bostwick CA. Fibroblasts in fibrosis: novel roles and mediators. Front Pharmacol 2014; 5: 123.

Eming SA, Wynn TA, Martin P. Inflammation and metabolism in tissue repair and regeneration. Science 2017; 356:1026-30.

Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med 2000; 6: 389-95.

Persson AB, Buschmann IR. Vascular growth in health and disease. Front Mol Neurosci 2011; 4: 14.

Tengood JE, Ridenour R, Brodsky R, Russell AJ, Little SR. Sequential delivery of basic fibroblast growth factor and platelet-derived growth factor for angiogenesis. Tissue Eng 2011; 17:1181-89.

Zymek P, Bujak M, Chatila K, Cieslak A, Thakker G, Entman ML, et al. The role of platelet-derived growth factor signaling in healing myocardial infarcts. J Am Coll Cardiol 2006; 48: 2315-23.

Matsui M, Tabata Y. Enhanced angiogenesis by multiple release of platelet rich plasma contents and basic fibroblast growth factor from gelatin hydrogels. Acta Biomater 2012; 8: 1792-801.

Lana JF, da Fonseca LF, Azzini G, Santos G, Braga M, Cardoso Junior AM, et al. Bone marrow aspirate matrix: a conveniently in regenerative medicine. Int J Mol Sci 2021; 22: 2762.

Cooke JP. Inflammation and its role in regeneration and repair. Circ Res. 2019; 124:1166-1168.

Sönmez TT, Vinogradov A, Zor F, Kweider N, Lippross S, Elisa Liehn A, et al. The effect of platelet rich plasma on angiogenesis in ischemic flaps in VEGFR2-luc mice. Biomaterials 2013; 34: 2674-82.

Downloads

Posted

2023-12-26

Section

Preprints

Categories