Key Features of SARS-CoV-2 and Available Therapies for COVID-19
Abstract
The disease caused by severe acute respiratory syndrome (SARS-CoV2) is highly pathogenic and communicable infection, progressed in Wuhan city of China and then goes viral around the globe. The Genomic investigations exposed that Phylogenetically SARS-CoV2 resembles the other SARS-like bat viruses, therefore bats were also considered as the possible potential reservoir for SARS-CoV2. There are 2 prevalent types of SARS-CoV2, L type (~70%) and S type (~30%).The L strains are considered more infectious and virulent than the ancestral S strain. The positive sense single-stranded RNA genetic material contains 29891 nucleotides which codes for 9860 amino acids. The ORF1a/b is involved in carrying the translation of two (2) polyproteins, pp1a and pp1ab as well as the encoding of 16 NSPs (Non-structural proteins), and the leftover ORFS can bring about the encoding of non-essential and structural proteins. The origination source and transmission to humankinds is still not clear, but the intermediate hosts are supposed to have a significant role in the transfer and emergence of SARS-CoV2 from bats to humans. There is still no approved drug or vaccine available for Covid-19. In the current review, we condense and fairly evaluate the emergence and pathogenicity of SARS-CoV2, SARS-CoV and MERS-CoV. Moreover, we also discuss the treatment and vaccine developments strategies for Covid-19.
Keywords:
Coronaviruses, COVID-19, Outbreak, SARS-CoV-2, TransmissionDownloads
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