Perspective on Accelerating the Mutation Rate of SARS-CoV-2 for a Better Way of COVID-19 Treatment
Enhanced Mutation Therapy of COVID-19
DOI:
https://doi.org/10.21467/preprints.62Abstract
“Higher the mutation rate higher is the possibility to evolve” and “higher the possibility to evolve higher is the possibility of extinction”. Since +ssRNA virus replication is catalyse by their own polymerase lacking proofreading activity have high mutation rate; further enhancement of mutation of SARS-CoV-2 using nucleotide analogues would be helpful to fight against COVID-19
Keywords:
SARS-CoV-2, Mutation, Remdesivir, Nucleotide Analogues, COVID-19Downloads
References
Forster P, Forster L, Renfrew C and Forster M (2020) Phylogenetic network analysis of SARS-CoV-2 genomes. Proc Natl Acad Sci USA, pii: 202004999. https://doi.org/10.1073/pnas.2004999117
Andersen KG, Rambaut A, Lipkin WI, Holmes EC and Garry RF (2020) The proximal origin of SARS-CoV-2. Nat Med, 26: 450-452. https://doi.org/10.1038/s41591-020-0820-9
Kim D, Lee JY, Yang JS, Kim JW, Kim VN and Chang H (2020) The architecture of SARS-CoV-2 transcriptome. Cell, pii: S0092-8674(20)30406-2. https://doi.org/10.1016/j.cell.2020.04.011
Cao B, Wang Y, et al. (2020) A trial of lopinavir-ritonavir in adults Hospitalized with Severe Covid-19. N Engl J Med, Mar 18. https://doi.org/10.1056/NEJMoa2001282
Grein J, Ohmagari N, et al. (2020) Compassionate use of remdesivir for patients with severe Covid-19. N Engl J Med, Apr 10. https://doi.org/10.1056/NEJMoa2007016
Peck KM and Lauring AS (2018) Complexities of viral mutation rates. J Virol, 92(14). pii: e01031-17. https://doi.org/10.1128/JVI.01031-17
Lynch M, Ackerman MS, et al. (2016) Genetic drift, selection and the evolution of the mutation rate. Nat Rev Genet 17:704–714. https://doi.org/10.1038/nrg.2016.104
Vignuzzi M, Stone JK, et al. (2006) Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population. Nature, 439: 344–348.
Timm A and Yin J (2012) Kinetics of virus production from single cells. Virology, 424: 11-17. https://doi.org/10.1016/j.virol.2011.12.005
Jordan PC, Stevens SK and Deval J (2018) Nucleosides for the treatment of respiratory RNA virus infections. Antivir Chem Chemother. 2018 Jan-Dec;26:2040206618764483. https://doi.org/10.1177/2040206618764483
Pachetti M, Marini B, et al. (2020) Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant. J Transl Med. 18: 179. https://doi.org/10.1186/s12967-020-02344-6
Wang C, Liu Z, Chen Z, Huang X, Xu M, He T and Zhang Z (2020) The establishment of reference sequence for SARS-CoV-2 and variation analysis. J Med Virol, 2020 Mar 13.https://doi.org/10.1002/jmv.25762
Patra SK (2020) Outfitting COVID-19: An effective therapeutic approach. AIJR Preprints, 41: Version-1. https://preprints.aijr.org/index.php/ap/preprint/view/41
Jennifer Abbasi J (2020) The promise and peril of antibody testing for COVID-19. JAMA, online April 17, 2020. https://doi.org/10.1001/jama.2020.6170
Downloads
Posted
Section
Categories
License
Copyright (c) 2020 Samir PATRA
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Any non-commercial use, distribution, adaptation, and reproduction in any medium is permitted as long as the original work is properly cited. However, caution and responsibility are required when reusing as the articles on the preprint server are not peer-reviewed. Readers are advised to check for the availability of any updated or peer-reviewed version.
